Is your outlook 2010 only stating in safe mode? A patch came out on Dec 8th’s Update (KB3114409) that was supposed to prevent safe mode, however it backfired.
See the notes below. I uninstalled the patch and now Outlook works perfectly. I’m guessing Microsoft will be pushing out a fix for this soon.
“This is about December 8, 2015, update for Outlook 2010 (KB3114409)
Today, I received a slew of updates via Windows Update. When I went to open Outlook 2010, it would ONLY open in Safe Mode. It would not open in regular (?) mode. After digging around for about 2 hours, and doing the usual disabling add-ins, etc., I found that this update is supposed to give Administrators the option to never have Outlook open in Safe Mode, among other fixes. See these 2 pages.
https://support.microsoft.com/en-us/kb/3114305. However, when I went to the registry to try to enable this, I found i didn’t have the referenced key.
However, for me, it seemed to do the opposite. It only allowed me to open in safe mode. Anyway, long story short, I uninstalled this update and after a reboot I could immediately open Outlook in normal mode.
Hopefully, this helps someone who may have had this issue.
And hopefully, it won’t reinstall itself and start the issue over again.”